It’s not surprising that the work we do in this industry is hard. We have to solve problems across multiple vectors – biology, chemistry, IT, regulatory and ethics, business systems … and economics. And the dollars matter. 

Some of the most brilliant ideas in biotech never make it to patients — not because of flawed science, but because of flawed funding models. Sho Chaudhuri is a scientist, MIT PhD holder, founder, and venture builder, and makes the case for capital efficiency as a design principle.

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About Shomesh (Sho)
Dr. Shomesh E. Chaudhuri co-founded QLS Advisors in 2019 and currently serves as the firm’s CEO and Co-CIO. Dr. Chaudhuri has developed portfolio intelligence platforms for several biopharma companies, consulting directly with CEOs, CFOs, and their staffs to help align their financing structures with their scientific and medical objectives. He has also led the development of the firm's core analytics platform, including QLS’s machine-learning driven forecasts of clinical trial outcomes, and has overseen the implementation of the entire QLS technology infrastructure and computational architecture.

Prior to QLS, Dr. Chaudhuri was a postdoctoral associate at MIT’s Sloan School of Management where he designed new funding vehicles and business models to access previously untapped pools of capital to support biomedical innovation. He has published articles in top finance and biotech journals including JAMA Oncology, the Journal of Financial Economics, and Management Science and is the co-author of the textbook Healthcare Finance: Modern Financial Analysis for Accelerating Biomedical Innovation. He holds a B.S, in engineering sciences (bioengineering) from Harvard University and an M.S. and Ph.D. in electrical engineering and computer science from MIT.

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Filmed at Innovation Network Gathering | West Chester, PA, USA | October 2025

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Credits:

• Event Production: Smith & Jones Innovation

• Direction & Speaker Support: Jeff Smith

• Production & Stage Management: Michelle Jones

• Stage Design & Lighting: Steve Harper | Indigo Design

• Video Capture: Armosa Studios

• Video Editing: Kyle Blackburn & Sigfried Seeliger

• Screen Assets & Video Engineer: Hunter Loveridge | Picture This

• Sound Engineer: George Koenig | Uptown! Knauer Center for Performing Arts