Dr. Irfan Khan is a cardiologist, principal investigator, and the Founder & CEO of Circuit Clinical. He works at the intersection of frontline care delivery and clinical research, focused on a simple but difficult question: why has clinical research become so disconnected from everyday medicine—and what would it take to change that? Through Circuit, Dr. Khan is helping expand research beyond resource-constrained academic centers into community health systems, where most patients actually receive their care. His work challenges long‑standing beliefs about who will say yes to clinical research participation and where clinical trials can succeed.

Dr. Khan is also deeply engaged in addressing the growing crisis in physician experience. As a practicing electrophysiologist, he has seen how misaligned systems, administrative burden, and extractive models contributed to soaring physician burnout - and how thoughtfully designed community research programs hold the promise of restoring purpose, agency, and curiosity to the practice of medicine. Dr. Khan serves as an advisor, investor, and board member to several notable startups, supporting teams that are rethinking how healthcare innovation is built and scaled.